A Sensitive Zinc-Activated super(129)Xe MRI Probe

Xenon capsule: A smart super(129)XeNMR-based sensor of Zn super(2+) ions for magnetic resonance imaging (MRI) is proposed. The resonance frequency of xenon encapsulated in a cryptophane that bears a nitrilotriacetic ligand moiety varies when Zn super(2+) ions are present in solution (see picture). W...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 51; no. 17; pp. 4100 - 4103
Main Authors:	Kotera, Naoko, Tassali, Nawal, Leonce, Estelle, Boutin, Celine, Berthault, Patrick, Brotin, Thierry, Dutasta, Jean-Pierre, Delacour, Lea, Traore, Tenin, Buisson, David-Alexandre, Taran, Frederic, Coudert, Sylvie, Rousseau, Bernard
Format:	Journal Article
Language:	English
Published:	01-04-2012
Subjects:	Encapsulation Gadolinium Ligands Magnetic resonance imaging Smart sensors Xenon Zinc
Online Access:	Get full text
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Summary:	Xenon capsule: A smart super(129)XeNMR-based sensor of Zn super(2+) ions for magnetic resonance imaging (MRI) is proposed. The resonance frequency of xenon encapsulated in a cryptophane that bears a nitrilotriacetic ligand moiety varies when Zn super(2+) ions are present in solution (see picture). With hyper-polarized gas, such a construct enables detection of 100nM zinc in one xenon batch, a threshold 300 times lower than achieved with gadolinium chelates.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201109194