Endometrial adenocarcinoma in spontaneous abortion: two cases and review of the literature

• Published in: International journal of clinical and experimental medicine Vol. 8; no. 5; pp. 8230 - 8233
• Main Authors: Zhou, Feng, Qian, Zhida, Li, Yinghua, Qin, Jiale, Huang, Lili
• Format: Report
• Language: English
• Published: 01-01-2015
• ISSN: 1940-5901; 1940-5901

OBJECTIVESTo report two extremely rare cases of endometrial adenocarcinoma established during the first trimester. CASE PRESENTATIONA 40-year-old (gravida 0, para 0) and 33-year-old (gravida 4, para 0) woman, were diagnosed with a well-differentiated adenocarcinoma after a dilatation and curettage (D&C) for spontaneous abortions at 8 and 9 gestational weeks, respectively. CONCLUSIONSThirty-six cases of pregnancy-associated endometrial cancer and 20 cases of first trimester pregnancy concurrent with endometrial carcinoma have been reported as present cases in the literature. Interestingly, 15 including our two cases were detected for spontaneous abortions in first-trimester suggesting a causal correlation between endometrial adenocarcinoma and spontaneous abortions. Repeated D&C and progesterone administration may be appropriate for patients who wish to preserve fertility.