Regulation of phospholipase A sub(2) in human leukemia cell lines: Its implication for intracellular signaling

Regulation of phospholipase A sub(2) in human leukemia cell lines: Its implication for intracellular signaling

Permeabilized human leukemia HL-60 and U-937 cells suspended in an acidic or alkaline medium release various unsaturated fatty acids, most abundantly oleic and arachidonic acids. Concomitant production of lysophospholipids suggests that phospholipases A sub(2) play a major role in this fatty acid re...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS Vol. 91; no. 14; pp. 6274 - 6278
Main Authors: Tsujishita, Y, Asaoka, Y, Nishizuka, Y
Format: Journal Article
Language:English
Published: 01-01-1994
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Summary:Permeabilized human leukemia HL-60 and U-937 cells suspended in an acidic or alkaline medium release various unsaturated fatty acids, most abundantly oleic and arachidonic acids. Concomitant production of lysophospholipids suggests that phospholipases A sub(2) play a major role in this fatty acid release reaction. The results imply that several phospholipases A sub(2) are coupled to receptors for their activation, thereby functioning in the transmembrane control of cellular events.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0027-8424