Regression of endometrial implants treated with vitamin D sub(3) in a rat model of endometriosis
Endometriosis is one of the most frequent gynecological diseases. In addition to their side effects, available medical therapies may decrease fertility. Current understanding of endometriosis focuses on the role of the immune system in its pathophysiology. Recent research shed light on the immunomod...
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| Published in: | European journal of pharmacology Vol. 715; no. 1-3; pp. 72 - 75 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-09-2013
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| Online Access: | Get full text |
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| Summary: | Endometriosis is one of the most frequent gynecological diseases. In addition to their side effects, available medical therapies may decrease fertility. Current understanding of endometriosis focuses on the role of the immune system in its pathophysiology. Recent research shed light on the immunomodulatory effect of vitamin D sub(3). Thus, this study was designed to study the effect of vitamin D sub(3) on regression of endometriotic implants in a rat surgical model. Vitamin D sub(3) reduced cyst cross sectional area by 48.8%. Histologically, vitamin D treatment produced fibrosis as well as apoptosis in the stroma. The results of the present study suggest that vitamin D sub(3) administration may have a beneficial effect in treating endometriosis. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2013.06.016 |