Evaluation of Institut Georges Lopez-1 Preservation Solution in Pig Pancreas Transplantation: A Pilot Study

• Published in: Transplantation Vol. 97; no. 9; p. np
• Main Authors: Garcia-Gil, Francisco A, Fuentes-Broto, Lorena, Albendea, Carlos D, Serrano, Maria Trinidad, Rosello-Catafau, Joan, Lampreave, Fermin, Lopez-Pingarron, Laura, Escartin, Jorge, Soria, Joaquin, Garcia, Joaquin J, Fernandez-Cruz, Laureano
• Format: Journal Article
• Language: English
• Published: 15-05-2014
• ISSN: 0041-1337

Background Institut Georges Lopez-1 preservation solution (IGL-1) is an emerging extracellular-type electrolyte solution, low in viscosity, containing polyethylene glycol 35 as a colloid. Although IGL-1 has shown beneficial outcomes in kidney and liver preservation, this pilot study is the first to equate the efficacy of IGL-1 in pancreas transplantation (PT) compared with the University of Wisconsin solution (UW). Methods Sixteen Landrace pigs underwent allogeneic PT with 16 hr of cold ischemia. Grafts were preserved with IGL-1 (n=8) or UW (n=8). No immunosuppression was administered. We analyzed graft function, the acute-phase response, and oxidative stress in the pancreatic graft monitoring membrane fluidity and lipid peroxidation. Results All eight grafts with IGL-1, but only six with UW, were functioning. Graft failures with UW resulted from graft thrombosis. There were no differences between the two solutions in the number of normoglycemic days (IGL-1: 11.5+ or -6.2 versus UW: 8.5+ or -4.4 days, P=0.1357), nor in lipid peroxidation during 16-hr cold ischemia (P=0.672), or reperfusion (P=0.185), but IGL-1 prevented changes in membrane fluidity after reperfusion when compared with UW (P=0.026). Conclusion IGL-1 offered the same degree of safety and effectiveness as UW in our model of pig PT with 16 hr of cold ischemia.