Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4 super(+) T cells

• Published in: Science (American Association for the Advancement of Science) Vol. 276; no. 5310; pp. 273 - 276
• Main Authors: Carroll, R G, Riley, J L, Levine, B L, Feng, Yu, Kaushal, S, Ritchey, D W, Bernstein, W, Weislow, O S, Brown, C R, Berger, E A, June, CH, St Louis, DC
• Format: Journal Article
• Language: English
• Published: 01-04-1997
• Subjects: human immunodeficiency virus 1
• ISSN: 0036-8075

Activation of CD4 super(+) T lymphocytes from human immunodeficiency virus-type 1 (HIV-1)-infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-1. Transcripts encoding CXCR4 /Fusin, the fusion cofactor used by T cell line-tropic isolates, were abundant in CD3/CD28-stimulated cells, but transcripts encoding CCR5, the fusion cofactor used by macrophage-tropic viruses, were not detectable. Thus, CD3/CD28 costimulation induces an HIV-1-resistant phenotype similar to that seen in some highly exposed and HIV-uninfected individuals.