Interpretation of super(14)C-urea and super(14)C-primidone extraction in isolated rabbit lungs

• Published in: Annals of biomedical engineering Vol. 24; no. 3; pp. 337 - 351
• Main Authors: Audi, SH, Dawson, CA, Linehan, J H, Krenz, G S, Ahlf, S B, Roerig, D L
• Format: Journal Article
• Language: English
• Published: 01-01-1996
• ISSN: 0090-6964

The venous concentration versus time curves of super(14)C-urea and super(14)C-primidone were measured after rapid bolus injections of a vascular reference indicator, fluorescein isothiocyanate dextran, and one of the two super(14)C-labeled indicators in isolated rabbit lungs perfused with Krebs-Ringer bicarbonate solution containing 4.5% bovine serum albumin at flow rates of 6.67, 3.33, 1.67, and 0.83 1/sec and with nearly constant microvascular pressure and total lung vascular volume. A new model has been found to explain the super(14)C-urea and super(14)C-primidone data with no flow-dependent change in the permeability-surface area product, (PS), suggesting that a change in PS with flow rates estimated using other models such as the Crone model is not sufficient evidence for capillary surface area recruitment.