Short synthesis of the natural product 3I2-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid

Short synthesis of the natural product 3I2-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid

Starting from labdanolic acid, extracted from Cistus ladaniferus plant, the first synthesis of the natural product 3I2-hydroxy-labd-8(17)-en-15-oic acid was achieved, via microbial transformation mediated by Penicillium janczewskii followed by dehydration. The structure of a new labdane diterpene, n...

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Bibliographic Details
Published in:Phytochemistry letters Vol. 6; no. 2; pp. 165 - 169
Main Authors: Frija, Luis, Garcia, Helga, Rodrigues, CA!tia, Martins, Isabel, Candeias, Nuno, Andre, VAcnia, Duarte, Maria, Pereira, Cristina, Afonso, Carlos
Format: Journal Article
Language:English
Published: 01-05-2013
Subjects:
Cistus
Penicillium janczewskii
Online Access:Get full text
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Summary:Starting from labdanolic acid, extracted from Cistus ladaniferus plant, the first synthesis of the natural product 3I2-hydroxy-labd-8(17)-en-15-oic acid was achieved, via microbial transformation mediated by Penicillium janczewskii followed by dehydration. The structure of a new labdane diterpene, namely 3I2-hydroxy-labdanolic acid, was elucidated by X-ray crystallography and spectroscopic data.
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ISSN:1874-3900
DOI:10.1016/j.phytol.2012.12.005