Voltage dependence of intracellular (Ca super(2+)) sub(i) transients in guinea pig ventricular myocytes
(Ca super(2+)) super(i) transients, elicited by voltage-clamp depolarization of single guinea pig cardiac ventricular cells, were observed through use of the fluorescent Ca super(2+) indicator, fura-2. The amplitude of slow fluorescence transients that are insensitive to verapamil and ryanodine incr...
Saved in:
| Published in: | Circulation research Vol. 61; no. 1; pp. 148 - 154 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-01-1987
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | (Ca super(2+)) super(i) transients, elicited by voltage-clamp depolarization of single guinea pig cardiac ventricular cells, were observed through use of the fluorescent Ca super(2+) indicator, fura-2. The amplitude of slow fluorescence transients that are insensitive to verapamil and ryanodine increases continuously with membrane potential throughout the range -20 to 80 mV. The voltage dependence and pharmacology of the rapid transients elicited by pulse depolarization or by repolarization are consistent with their having arisen from Ca super(2+) released from the sarcoplasmic reticulum, via Ca super(2+)-induced Ca super(2+) release. |
|---|---|
| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
| ISSN: | 0009-7330 |