A randomized trial of timentin and tobramycin versus piperacillin and tobramycin in febrile neutropenic patients

• Published in: Antimicrobial agents and chemotherapy Vol. 17; p. no. sul. C
• Main Authors: Mackie, MJ, Reilly, J T, Purohit, S, Bartzokas, CA
• Format: Journal Article
• Language: English
• Published: 01-01-1986
• ISSN: 0066-4804

The efficacy of ticarcillin and clavulanic acid (Timentin) was assessed in a regimen combined with tobramycin in febrile episodes in neutropenic patients. After randomization, 151 patients were assessable following treatment with either Timentin and tobramycin or piperacillin and tobramycin. The overall success rate was 70% in the Timentin and tobramycin group and 71% when piperacillin and tobramycin were given; when no infection could be demonstrated efficacy was 73% in the Timentin group, 65% when only clinical or radiological evidence of infection was present and 63% with conclusive microbiology. In septicaemic patients, the Timentin regimen was effective in 55% of cases, while the piperacillin group was successful in 40%. Timentin is a useful addition to the agents suitable for the treatment of febrile neutropenic patients.