Targeted delivery of paclitaxel-loaded recombinant [alpha]-fetoprotein fragment-conjugated nanoparticles to tumor cells

• Published in: Doklady. Biochemistry and biophysics Vol. 439; no. 1; p. 158
• Main Authors: Godovannyi, A V, Vorontsov, E A, Gukasova, N V, Pozdnyakova, N V, Vasilenko, E A, Yabbarov, N G, Dubovik, E G, Severin, S E, Severin, E S, Gnuchev, N V
• Format: Journal Article
• Language: English
• Published: Moscow Springer Nature B.V 01-08-2011
• Subjects: Chemotherapy; Cytotoxicity; Drug delivery systems; Drug resistance; Tumors
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S160767291104003X

Godovannyi et al previously proposed a method for targeted delivery of cytotoxic drugs into tumor cells using alpha fetoprotein (AFP) as a vector molecule. They demonstrated that the AFP receptor can be used as a universal target for selective delivery of chemotherapeutic agents. In continuation of that work, they obtained the recombinant C terminal domain of AFP that selectively binds to AFPR and showed that it can be effectively used as a vector molecule for selective delivery of the anticancer drug cisplatin .