Spirocyclization bygem-dialkylation at carbonyl carbons. Total synthesis of 13-noraphidicolin

Spirocyclization bygem-dialkylation at carbonyl carbons. Total synthesis of 13-noraphidicolin

Studies directed at the total synthesis of 13-noraphid-icolin are described. Initial studies were aimed at the development of a vinylstannane- or vinylsilane-mediated intramolecular spirocyclization. The target compound was prepared in fourteen steps by ketonization of a toluenesulfonyl olefin with...

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Bibliographic Details
Main Author: Huber, Scot Kevin
Format: Dissertation
Language:English
Published: ProQuest Dissertations & Theses 01-01-1992
Subjects:
Organic chemistry
Pharmacology
Online Access:Get full text
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Summary:Studies directed at the total synthesis of 13-noraphid-icolin are described. Initial studies were aimed at the development of a vinylstannane- or vinylsilane-mediated intramolecular spirocyclization. The target compound was prepared in fourteen steps by ketonization of a toluenesulfonyl olefin with disodium tetracarbonylferrate.
ISBN:9798641346205