Exploration of Mechanisms that Govern Tumorigenesis and Anti-tumor Immunity in Pancreatic Cancer
This thesis work will approach the topic of pancreatic ductal adenocarcinoma (PDA) intractability in two distinct parts. The first chapter (Chapter 1; Pages 16–86) will cover the interplay between the systemic immune system, aerobic exercise, and tumor growth in pancreatic cancer. Focusing specifica...
Saved in:
| Main Author: | |
|---|---|
| Format: | Dissertation |
| Language: | English |
| Published: |
ProQuest Dissertations & Theses
01-01-2022
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | This thesis work will approach the topic of pancreatic ductal adenocarcinoma (PDA) intractability in two distinct parts. The first chapter (Chapter 1; Pages 16–86) will cover the interplay between the systemic immune system, aerobic exercise, and tumor growth in pancreatic cancer. Focusing specifically on the potential anti-tumor and immune-activating effects of aerobic exercise, the work herein will describe the therapeutic potential and mechanisms that underlie an exercise-oncology axis in this disease. The second chapter (Chapter 2; Pages 87–145) will approach the topic of aberrant glycosylation in PDA, an emerging hallmark of cancer that contributes to both treatment resistance and immune-suppression. In particular, the work herein will use lectin array technology detecting glycosylation-epitopes in both human and murine tissues to identify glyco-related genes that promote tumor growth. In aggregate, this work highlights the contribution of systemic immune mobilization to PDA anti-tumor immunity and underscores the contribution of glycosylation to PDA development. |
|---|---|
| ISBN: | 9798837545207 |