Clinical and Metabolic Characterization of Bronco-Pulmonary Carcinoma in Surgical Stadium

Clinical and Metabolic Characterization of Bronco-Pulmonary Carcinoma in Surgical Stadium

Bronchial-Pulmonary carcinomas (BPC) present in advanced stages in nearly 70% of cases. Clinical and pathological criteria have to be strict to fulfil personalized therapy and direct molecular pathology. The 18F-Flourodeoxiglucose (FDG) uptake integrates clinical diagnosis and we hypothesized that F...

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Bibliographic Details
Main Author: de Castro e Dias, José Alberto
Format: Dissertation
Language:English
Published: ProQuest Dissertations & Theses 01-01-2012
Subjects:
Age
Biopsy
Brain research
Cancer therapies
Cell growth
Cellular biology
Cloning
Endocrinology
Gender
Genetics
Genomes
Glucose
Liver cancer
Medical imaging
Medical prognosis
Medical research
Medicine
Metabolism
Mitochondrial DNA
Mutation
Neurosciences
Oncology
Pathology
Pharmaceutical sciences
Thyroid gland
Tumors
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Summary:Bronchial-Pulmonary carcinomas (BPC) present in advanced stages in nearly 70% of cases. Clinical and pathological criteria have to be strict to fulfil personalized therapy and direct molecular pathology. The 18F-Flourodeoxiglucose (FDG) uptake integrates clinical diagnosis and we hypothesized that FDG uptake together with CK7, CK5.6/p63, TTF1, CD56, Vimentin expression and mitochondrial DNA (mtDNA) content define criteria to stratify lung cancer in small biopsies.A series of 40 surgical specimens whose patients had preoperative Positron Emission Tomography/Computed Tomography (PET/CT) was introduced in this study by recurring to archive tissue to submit to immunohistochemistry (IHC) and mtDNA validation.WHO 2004 and IASLC/ATS/ERS 2011 proposal classifications were applied to correlate with the previous parameters.TTF1 Positive adenocarcinomas had lower 18F-FDG uptake (p=0,006) compared with TTF1 negative adenocarcinomas and these equal epidermoid carcinomas (p=0,396). Here called complex group of the other histological types have 18F-FDG uptake intermingled with the other types needed reliable IHC to subclassification; mtDNA correlated with 18F-FDG uptake (p=0.0059).As an approach to subclassify BPC in small biopsies, 18F-FDG uptake together with IHC defined panel will allow stratification for personalized therapy and clinical follow up: epidermoid carcinoma, bronchial adenocarcinoma, TRU adenocarcinoma, adenosquamous
ISBN:9798819346327