Decoding Host-Pathogen Interaction Networks to Understand Viral Life Cycles and Host Response

The human body is a complex ‘megalopolis’ of organs, tissues, cells, and molecules thatgovern harmonious homeostatic flow that functions as a flexible system capable to adjust tofluctuations caused by external stressors. On the other hand, a seemingly simple viral particle ispowerful enough to invad...

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Bibliographic Details
Main Author: Delgado-Moshkina, Natasha
Format: Dissertation
Language:English
Published: ProQuest Dissertations & Theses 01-01-2020
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Summary:The human body is a complex ‘megalopolis’ of organs, tissues, cells, and molecules thatgovern harmonious homeostatic flow that functions as a flexible system capable to adjust tofluctuations caused by external stressors. On the other hand, a seemingly simple viral particle ispowerful enough to invade a host and cause the butterfly effect ultimately altering nearly everyhost’s cell. Viral perturbations in cellular homeostasis can result in misbalance of an entireorganism and lead to a diseased state. This work is dedicated to investigation of host-pathogenrelationships in an effort to understand how viral invasion manipulates the host immuneresponse and causes diseases. Specifically, we address pathogenicity of influenza virus and applyinfection as a tool for identifying genetic components that regulate inflammatory response inhuman cells. Our goal is to study mechanisms that underlie the innate immune response byinterrogating i) virus-host protein-protein interactions, ii) changes in the gene expression profileinduced by influenza virus infection, and iii) new candidate genes mutated in diseases.
ISBN:9798516930706