Characterization of Sgo1 Expression and Localization in Developing and Adult Mouse

SGO1 has been characterized in its function in correct cell division and its role in centrosome cohesion. However, its organ-specific maturation-related expression pattern in vivo remains largely uncharacterized. Here, we show clear Sgo1 expression in post-developmental neuronal cells and cytoplasmi...

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Bibliographic Details
Main Author:	Song, Andrew Taehun
Format:	Dissertation
Language:	English
Published:	ProQuest Dissertations & Theses 01-01-2017
Subjects:	Cardiac arrhythmia Cell division Cellular biology Electrocardiography Heart Localization Mutation Physiology Smooth muscle
Online Access:	Get full text
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Summary:	SGO1 has been characterized in its function in correct cell division and its role in centrosome cohesion. However, its organ-specific maturation-related expression pattern in vivo remains largely uncharacterized. Here, we show clear Sgo1 expression in post-developmental neuronal cells and cytoplasmic localization in nucleated cells with a transgenic mice model and immunohistochemistry of wild type mice. We demonstrate extranuclear expression of Sgo1 in the developing heart and gut, organs which have been shown to be dysregulated in humans with homozygous SGO1 mutation. Additionally, we show Sgo1 expression in select population of retinal cells in developing and post-developmental retina. Our expression analysis strongly suggests that the function of SGO1 goes beyond its well characterized role in cell division.
ISBN:	9798582581772