Expression of CD3 complexes by native and UV-irradiated T lymphocytes from human blood upon treatment with Leukocytic [alpha]-interferon

Expression of CD3 complexes by native and UV-irradiated T lymphocytes from human blood upon treatment with Leukocytic [alpha]-interferon

The influence of leukocytic α-interferon on the expression of CD3 complexes by native and UV-irradiated T cells from human blood has been studied. Irradiation at doses of 151-906 J/m2 increased the quantity of CD3 complexes on the surface of their membranes, whereas a dose of 1359 J/m2 decreased it....

Full description

Saved in:
Bibliographic Details
Published in:Biophysics (Oxford) Vol. 54; no. 2; p. 177
Main Authors: Artyukhov, V G, Putintseva, O V, Koltakov, I A, Vdovina, V A
Format: Journal Article
Language:English
Published: Moscow Springer Nature B.V 01-04-2009
Subjects:
Antigens
Biophysics
Blood
Cytokines
Interferon
Lymphocytes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The influence of leukocytic α-interferon on the expression of CD3 complexes by native and UV-irradiated T cells from human blood has been studied. Irradiation at doses of 151-906 J/m2 increased the quantity of CD3 complexes on the surface of their membranes, whereas a dose of 1359 J/m2 decreased it. Subsequent incubation with the cytokine (0.01-100 IU/ml) could level off the stimulatory effect of "therapeutic" UV doses but reversed the CD3-suppressive effect of the maximal UV dose. These data may be important with regard to combined therapy. [PUBLICATION ABSTRACT]
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350909020109