Ligands bind to Sortilin in the tunnel of a ten-bladed [beta]-propeller domain

The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2 angstroms resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for exam...

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Bibliographic Details
Published in:	Nature structural & molecular biology Vol. 16; no. 1; p. 96
Main Authors:	Quistgaard, Esben M, Madsen, Peder, Grøftehauge, Morten K, Nissen, Poul, Petersen, Claus M, Thirup, Søren S
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group 01-01-2009
Subjects:	Binding sites Competition Molecular biology Molecular structure
Online Access:	Get full text
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Summary:	The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2 angstroms resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for example, for the prodomain of nerve growth factor-beta, are present in the tunnel and that competition for binding relates to the restricted space inside the propeller. [PUBLICATION ABSTRACT]
ISSN:	1545-9993 1545-9985
DOI:	10.1038/nsmb.1543