Single Molecule Spectroscopy Study on Fluorescence Enhancement by Noble Metal Nanoparticles
Noble metal nanoparticles (NPs) exhibit unique optical properties owing to their localized surface plasmon resonance (LSPR). Optical signals, such as fluorescence, Raman Scattering, and non-linear responses have been found enhanced with presence of such noble metal NPs. As the most widely used imagi...
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| Format: | Dissertation |
| Language: | English |
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ProQuest Dissertations & Theses
01-01-2015
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| Online Access: | Get full text |
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| Summary: | Noble metal nanoparticles (NPs) exhibit unique optical properties owing to their localized surface plasmon resonance (LSPR). Optical signals, such as fluorescence, Raman Scattering, and non-linear responses have been found enhanced with presence of such noble metal NPs. As the most widely used imaging and spectroscopic technique, fluorescence and its enhancement have drawn tremendous interest in both fundamentals and applications. This thesis covers authors’ own work in the study of metal enhanced fluorescence at single molecule level. It starts with a numerical study on factors affecting fluorescence enhancement capability. Parameters such as molecule-NP distance, LSPR and emission wavelength, NP size have been studied systematically in a multidimensional parameter space for the optimized conditions. It has been found NP size played critical rules determining whether LSPR could enhance or quench fluorescence of a molecule. Moreover, the LSPR wavelength should be around 60 nm shorter than the fluorescence emission wavelength in order to have optimal fluorescence enhancement. Such simulation studies provide guidance to experiments for optimized fluorescence enhancement. |
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| ISBN: | 9781073971497 107397149X |