A hierarchy of epigenetic changes in the developmental transition from brown to white perirenal adipose tissue

The developmental transition of the ovine perirenal adipose tissue depot from late gestation to a few weeks after birth shows a rapid change from brown to white adipose tissue. These tissues are functionally and morphologically distinct. The former protects the newborn from hypothermia, whereas the...

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Bibliographic Details
Published in:	Journal of animal science Vol. 94; pp. 9 - 10
Main Authors:	Vuocolo, T, Statham, A, Bauer, D C, McWilliam, S, Nair, S S, Morrison, J L, Zhang, S, Buckley, M, McMillen, I C, Clark, S J, Tellam, R L
Format:	Journal Article
Language:	English
Published:	Champaign Oxford University Press 01-09-2016
Subjects:	Adipose tissue Chromatin Deoxyribonucleic acid DNA DNA methylation Energy balance Epigenetics Gene expression Genomes Gestation Homeostasis Hypothermia Sheep Tissues
Online Access:	Get full text
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Summary:	The developmental transition of the ovine perirenal adipose tissue depot from late gestation to a few weeks after birth shows a rapid change from brown to white adipose tissue. These tissues are functionally and morphologically distinct. The former protects the newborn from hypothermia, whereas the latter is involved in energy homeostasis during a period of rapid growth and nutritional change. Here, an abstract of an article by Bauer et al investigating the epigenetic landscape underpinning this transition using genome-wide analyses of chromatin modifications (ChIP-Seq), DNA methylation (WGBS), and gene transcription (RNASeq) is presented.
ISSN:	0021-8812 1525-3163