EFFECT OF PREPROCEDURAL HEPARIN ADMINISTRATION ON BIVALIRUDIN-BASED ANTICOAGULATION STRATEGY DURING PRIMARY PERCUTANEOUS CORONARY INTERVENTION: A NETWORK META-ANALYSIS

EFFECT OF PREPROCEDURAL HEPARIN ADMINISTRATION ON BIVALIRUDIN-BASED ANTICOAGULATION STRATEGY DURING PRIMARY PERCUTANEOUS CORONARY INTERVENTION: A NETWORK META-ANALYSIS

Background Early RCTs have shown that for primary PCI, bivalirudin is associated with an increased risk of stent thrombosis compared to heparin, thus attenuating its efficacy in terms of preventing net adverse clinical events (NACEs) and mortality. [...]recent RCTs have suggested that pre-procedural...

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Bibliographic Details
Published in:Journal of the American College of Cardiology Vol. 71; no. 11; p. A1402
Main Authors: Shah, Rahman, Nayyar, Mannu, Beatrix Ramos Bondy, Chaudhry, Amina, Butt, Arsa K, Shell, Abigail, Rogers, Kelly
Format: Journal Article
Language:English
Published: New York Elsevier Limited 10-03-2018
Subjects:
Angioplasty
Anticoagulants
Cardiology
Coagulation
Heparin
Meta-analysis
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Summary:Background Early RCTs have shown that for primary PCI, bivalirudin is associated with an increased risk of stent thrombosis compared to heparin, thus attenuating its efficacy in terms of preventing net adverse clinical events (NACEs) and mortality. [...]recent RCTs have suggested that pre-procedural unfractionated heparin (UFH) administration may eliminate this risk. [...]we performed a network meta-analysis of RCTs to evaluate the effect of pre-procedural UFH on bivalirudin-based anticoagulant therapy for primary PCI.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(18)31943-0