IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma1

IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma1

IL-4 is a pleiotropic immune cytokine secreted by activated TH2 cells that inhibits bone resorption both in vitro and in vivo. The cellular targets of IL-4 action as well as its intracellular mechanism of action remain to be determined.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS Vol. 98; no. 5; p. 2443
Main Authors: Bendixen, Amy C, Shevde, Nirupama K, Dienger, Krista M, Wilson, Timothy M
Format: Journal Article
Language:English
Published: Washington National Academy of Sciences 27-02-2001
Subjects:
Bones
Cellular biology
Proteins
Online Access:Get full text
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Description
Summary:IL-4 is a pleiotropic immune cytokine secreted by activated TH2 cells that inhibits bone resorption both in vitro and in vivo. The cellular targets of IL-4 action as well as its intracellular mechanism of action remain to be determined.
ISSN:0027-8424
1091-6490