Analysis of tensile strength of poly(lactic-co-glycolic acid) (PLGA) membranes used for guided tissue regeneration

• Published in: Revista Sul-Brasileira de odontologia Vol. 11; no. 1; pp. 59 - 65
• Main Authors: de Sousa, Bruno Gasparini Betiatto, Pedrotti, Gabrielle, Sponchiado, Ana Paula, Cunali, Rafael Schlögel, Aragones, Águedo, Sarot, João Rodrigo, Zielak, João Cézar, Ornaghi, Bárbara Pick, Leão, Moira Pedroso
• Format: Journal Article
• Language: English
• Published: Joinville Universidade da Região de Joinville - Univille, Revista RSBO 01-01-2014
• Subjects: Biomedical materials; Glycolic acid; Humidity; Membranes; Regeneration (physiology); Surgical implants; Tensile strength; Tensile tests; Tissue engineering
• ISSN: 1806-7727; 1984-5685

Introduction: The challenge of restoring patient's function that presented some loss of an organ or tissue encourages the Tissue Engineering and Biotechnology to develop materials that promote bone regeneration. Poly(lactic-co-glycolic acid) (PLGA) copolymer is among of the most biomaterials used. Objective: To evaluate the tensile strength of PLGA membranes at different conditions of humidity and temperature. Material and methods: PLGA membranes were hourglass-shape cut and prepared at three different conditions of temperature and humidity (n = 10): (I) dry membrane at environment temperature of about 20°C (control group), (II) moist membrane plasticized at 55°C, (III) moist membrane plasticized at 55°C, which subsequently underwent cooling. Subsequently, the membranes were subjected to tensile tests in a universal testing machine (DL-2000, EMIC) at 1.0 mm/min. Data was submitted to ANOVA and Tukey's test (p < 0.05). Results: Group I showed the highest tensile strength mean (16.7 ± 1.9a MPa, p = 0.0022). There was no statistically significant difference between the means of groups II (14.6 ± 1.4 MPab) and III (13.9 ± 1.7 MPab). Conclusion: The dried PLGA membranes showed higher tensile strength than the membranes that were only either plasticized or cooled.