D28 THE WEB OF OMICS: DNA, RNA, AND PROTEIN MODIFICATIONS: Association Between Dna Methylation In The Axl Gene At Birth And Childhood Respiratory Health

D28 THE WEB OF OMICS: DNA, RNA, AND PROTEIN MODIFICATIONS: Association Between Dna Methylation In The Axl Gene At Birth And Childhood Respiratory Health

Methods DNA methylation at birth was measured from newborn blood spots using the Illumina HumanMethylation450 array on a subset of 273 children from the Children's Health Study (CHS). Conclusions AXL DNA methylation at birth was associated with higher risk for asthma symptoms in early childhood...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine Vol. 195
Main Authors: Gao, L, Millstein, J, Siegmund, K, Dubeau, L, Avol, E, Gilliland, F, Breton, C
Format: Journal Article
Language:English
Published: New York American Thoracic Society 01-01-2017
Subjects:
Asthma
Children & youth
Deoxyribonucleic acid
DNA
DNA methylation
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Summary:Methods DNA methylation at birth was measured from newborn blood spots using the Illumina HumanMethylation450 array on a subset of 273 children from the Children's Health Study (CHS). Conclusions AXL DNA methylation at birth was associated with higher risk for asthma symptoms in early childhood and may reflect differences in fetal programming of the immune response that affect risk of asthma and wheezing in childhood.
ISSN:1073-449X
1535-4970