A95 ACUTE PNEUMONIA: CLINICAL STUDIES: Predicting Pneumonia: A Prospective Observational Study Of The Risk Factors For Hospital-Acquired And Ventilator-Associated Bacterial Pneumonia

• Published in: American journal of respiratory and critical care medicine Vol. 195
• Main Authors: Bergin, S P, Coles, A, Farley, J, Santiago, J, Calvert, S, Fowler, V G, Holland, T L
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 01-01-2017
• Subjects: Antibiotics; Clinical trials; Observational studies; Pneumonia; Sepsis; Ventilators
• ISSN: 1073-449X; 1535-4970

RATIONALE Frequent infection with multidrug-resistant pathogens and demonstrated limitations of many available antibacterial agents complicate the treatment of hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP), underscoring the urgent need for new antibacterial drugs proven effective in high-quality clinical trials. Patients hospitalized for at least 48 hours and supported with invasive mechanical ventilation (IMV), noninvasive ventilation (NIV), or high levels of supplemental oxygen were classified as high-risk for the development of HABP/VABP and monitored daily for receipt of antibiotics to treat possible lower respiratory tract infection (LRTI) or undifferentiated sepsis. From study entry, patients were followed to determine if they developed the primary outcome of HABP/VABP defined by meeting recommended trial inclusion criteria per US Food and Drug Administration (FDA) guidance.