A74 REGULATORY MECHANISMS OF THE MOLECULAR PATHWAYS IN FIBROSIS: Expression Of β-Catenin-Induced Transcription Regulators B-Cell Cll/lymphoma 9 (bcl9) And Naked-1 (nkd1) In Idiopathic Pulmonary Fibrosis

A74 REGULATORY MECHANISMS OF THE MOLECULAR PATHWAYS IN FIBROSIS: Expression Of β-Catenin-Induced Transcription Regulators B-Cell Cll/lymphoma 9 (bcl9) And Naked-1 (nkd1) In Idiopathic Pulmonary Fibrosis

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is believed to be the result of aberrant regeneration and dysfunctional Wnt/ß-catenin activation. ß-catenin is involved in cellular processes such as differentiation, proliferation, migration and vascularization. BCL9, when part of the ß-catenin-transcr...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine Vol. 195
Main Authors: Rydell-Tormanen, K, Einarsson, J, Zhou, X-H, Hallgren, O, Andersson-Sjoland, A, Eriksson, L, Westergren-Thorsson, G
Format: Journal Article
Language:English
Published: New York American Thoracic Society 01-01-2017
Subjects:
Fibroblasts
Lungs
Lymphoma
Pulmonary fibrosis
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Summary:BACKGROUND Idiopathic pulmonary fibrosis (IPF) is believed to be the result of aberrant regeneration and dysfunctional Wnt/ß-catenin activation. ß-catenin is involved in cellular processes such as differentiation, proliferation, migration and vascularization. BCL9, when part of the ß-catenin-transcription complex, is known to be involved in EMT. [...]this result may represent a new mechanism for early IPF, and highlights the importance of ß-catenin transcription, and transcriptional regulators in IPF.
ISSN:1073-449X
1535-4970