C75 FIBROSIS: CURRENT AND FUTURE APPROACHES: Alveolar Epithelial Cell Endoplasmic Reticulum Stress Impairs Antiviral Immunity In The Lung

C75 FIBROSIS: CURRENT AND FUTURE APPROACHES: Alveolar Epithelial Cell Endoplasmic Reticulum Stress Impairs Antiviral Immunity In The Lung

Rationale: Endoplasmic reticulum (ER) stress is common in alveolar epithelial cells (AECs) in lungs from patients with idiopathic pulmonary fibrosis (IPF). At 2 weeks post-infection, L188Q SFTPC mice had increased total and lytic virus in the lung, along with more total inflammatory cells and increa...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine Vol. 195
Main Authors: Kropski, J, Calvi, C, Cheng, D-S, Serezani, A, Zaynagetdinov, R, Polosukhin, I V, Polosukhin, V V, Tanjore, H, Lawson, W, Blackwell, T S
Format: Journal Article
Language:English
Published: New York American Thoracic Society 01-01-2017
Subjects:
Antigens
Antiviral drugs
Cytomegalovirus
Endoplasmic reticulum
Flow cytometry
Infections
Interferon
Lungs
Pulmonary fibrosis
Rodents
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Summary:Rationale: Endoplasmic reticulum (ER) stress is common in alveolar epithelial cells (AECs) in lungs from patients with idiopathic pulmonary fibrosis (IPF). At 2 weeks post-infection, L188Q SFTPC mice had increased total and lytic virus in the lung, along with more total inflammatory cells and increased levels of interferon gamma, although T-cell subsets were similar between groups.
ISSN:1073-449X
1535-4970