C73 NEW MECHANISMS AND THERAPIES IN COPD: Decreased Level Of Irisin, A Skeletal Muscle Cell-Derived Myokine, Is Involved In Emphysema Associated With Chronic Obstructive Pulmonary Disease Through Epithelial Apoptosis

Irisin is a skeletal muscle cell-derived myokine, and recently reported to decrease oxidative stress-induced apoptosis in diabetes mellitus subjects. The effect of irisin on cigarette smoke extract (CSE) induced A549 cell apoptosis and Nrf2 expression level was also examined in vitro.

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 195
Main Authors:	Sugiyama, Y, Asai, K, Kojima, K, Sugitani, A, Kubo, H, Kyomoto, Y, Yoshida, S, Yamada, K, Yoshii, N, Watanabe, T, Uji, M, Tochino, Y, Kanazawa, H, Hirata, K
Format:	Journal Article
Language:	English
Published:	New York American Thoracic Society 01-01-2017
Subjects:	Apoptosis Chronic obstructive pulmonary disease Emphysema Musculoskeletal system
Online Access:	Get full text
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Description
Summary:	Irisin is a skeletal muscle cell-derived myokine, and recently reported to decrease oxidative stress-induced apoptosis in diabetes mellitus subjects. The effect of irisin on cigarette smoke extract (CSE) induced A549 cell apoptosis and Nrf2 expression level was also examined in vitro.
ISSN:	1073-449X 1535-4970