GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates: Letter

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates Letter

This letter describes the detection of GGPS1 and other mutations in three sisters who had atypical femoral fractures associated with long-term bisphosphonate use, which suggests that genes in the isoprenoid biosynthetic pathway may confer susceptibility to atypical fractures.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 376; no. 18; pp. 1794 - 1795
Main Authors: Roca-Ayats Neus, Balcells Susana, Garcia-Giralt, Natàlia, Falcó-Mascaró Maite, Martínez-Gil, Núria, Abril, Josep F, Urreizti Roser, Dopazo Joaquín, Quesada-Gómez, José M, Nogués Xavier, Mellibovsky Leonardo, Prieto-Alhambra, Daniel, Dunford, James E, Javaid, Muhammad K, Graham, Russell R, Grinberg, Daniel, Díez-Pérez Adolfo
Format: Journal Article
Language:English
Published: Boston Massachusetts Medical Society 04-05-2017
Subjects:
Drug use
Fractures
Genes
Legs
Mutation
Pharmaceuticals
Online Access:Get full text
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Description
Summary:This letter describes the detection of GGPS1 and other mutations in three sisters who had atypical femoral fractures associated with long-term bisphosphonate use, which suggests that genes in the isoprenoid biosynthetic pathway may confer susceptibility to atypical fractures.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1612804