Contribution of CDKAL1 rs7756992 and IGF2BP2 rs4402960 polymorphisms in type 2 diabetes, diabetic complications, obesity risk and hypertension in the Tunisian population 群CDKAL1 rs7756992IGF2BP2 rs44029602è-å

• Published in: Journal of diabetes Vol. 7; no. 1; p. 102
• Main Authors: Lasram, Khaled, Ben Halim, Nizar, Benrahma, Houda, Mediene-Benchekor, Sounnia, Arfa, Imen, Hsouna, Sana, Kefi, Rym, Jamoussi, Henda, Ben Ammar, Slim, Bahri, Sonia, Abid, Abdelmajid, Benhamamouch, Soraya, Barakat, Abdelhamid, Abdelhak, Sonia
• Format: Journal Article
• Language: English
• Published: Hoboken John Wiley & Sons, Inc 01-01-2015
• Subjects: Cardiovascular disease; Diabetes; Diabetic retinopathy; Hypertension; Obesity
• ISSN: 1753-0393; 1753-0407
• DOI: 10.1111/1753-0407.12147

Background The insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and the cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) identified through genome-wide association (GWA) studies have been shown to be associated with Type 2 diabetes in various ethnic groups. In this study, we investigated the association of the rs7756992 of CDKAL1 and the rs4402960 of IGF2BP2 with Type 2 diabetes, diabetic complications (nephropathy, retinopathy and cardiovascular disease), obesity and hypertension in a Tunisian population. Methods A case-control association study including 200 Type 2 diabetes Tunisian patients (World Health Organization criteria) and 208 controls (age ≥40; fasting plasma glucose <6.1mmol/L; without first degree family history of diabetes) has been performed. Other parameters such as diabetic nephropathy, diabetic retinopathy, cardiovascular disease, overweight/obesity and hypertension have been also collected. Genotyping was performed using TaqMan technology. Results A significant association between the rs4402960 and Type 2 diabetes (OR = 1.86, 95% CI = 1.34-2.58, P < 10-4) has been found. Overweight/obese subjects bearing the T-allele have an increased risk to develop Type 2 diabetes (OR = 2.06, 95% CI = 1.40-3.03, P < 10-4). Furthermore, the rs7756992 was found to be associated with the reduced risk of diabetic nephropathy in patients with diabetes (OR = 0.44, 95% CI = 0.27-0.73, P = 0.001). Conclusions The present study confirms that the rs4402960 of IGF2BP2 gene is a strong candidate for Type 2 diabetes susceptibility and overweight/obesity risk in the Tunisian population. Interestingly, our data suggest that the rs7756992 of CDKAL1 gene have a protective effect against diabetic nephropathy.