Interferon and other proinflamatory cytokine responsesin vitrofollowing infection with wild-type and cold-adapted reassortant influenza viruses

Interferon and other proinflamatory cytokine responsesin vitrofollowing infection with wild-type and cold-adapted reassortant influenza viruses

To better understand the relationship between attenuation and induction of innate immunity as well as contribution of the proinflammatory cytokine response to the relative immunogenicity of live attenuated influenza vaccines, we have studied cytokine response in human cells of epithelial and macroph...

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Bibliographic Details
Published in:Vaccine Vol. 24; no. 44-46; p. 6581
Main Authors: Rekstin, AR, Kiseleva, IV, Klimov, AI, Katz, JM, Rudenko, LG
Format: Journal Article
Language:English
Published: Kidlington Elsevier Limited 10-11-2006
Subjects:
Amino acids
Antibiotics
Bioassays
Cytokines
Eggs
Genes
Immune system
Immunogenicity
Infections
Swine flu
Vaccines
Viruses
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Summary:To better understand the relationship between attenuation and induction of innate immunity as well as contribution of the proinflammatory cytokine response to the relative immunogenicity of live attenuated influenza vaccines, we have studied cytokine response in human cells of epithelial and macrophage origin in response to infection with single gene reassortants between A/Leningrad/134/17/57 (H2H2) cold-adapted master donor strain and epidemic wild-type (wt) A/Leningrad/134/57 (H2N2) influenza virus. Cells Production of proinflammatory cytokines were studied in THP-1 human macrophage (ATCC #TIB-202) and A549 human lung carcinoma (epithelial) (ATCC #CCL-185) cell lines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2006.05.091