A Kinetic Study on Drug Distribution

To rationalize the observed time courses of furosemide distribution in arbitrarily selected tissues of rats, a phaarmacokinetic analysis based on the perfusion rate-limited model was carried out. Anatomical compartments include liver, kidneys, intestine, muscle and plasma. Required parameters were e...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 36; no. 3; p. 1053
Main Authors:	KITANI, MAMI, OZAKI, YUKIKO, KITAYAMA, KAZUNORI, KAKEMI, MASAWO, KOIZUMI, TAMOTSU
Format:	Journal Article
Language:	English
Published:	Tokyo Japan Science and Technology Agency 01-03-1988
Online Access:	Get full text
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Summary:	To rationalize the observed time courses of furosemide distribution in arbitrarily selected tissues of rats, a phaarmacokinetic analysis based on the perfusion rate-limited model was carried out. Anatomical compartments include liver, kidneys, intestine, muscle and plasma. Required parameters were estimated on the basis of physiological principles for rats.
ISSN:	0009-2363 1347-5223