Cover Picture: Chemical Protein Synthesis by Chemoselective [alpha]-Ketoacid-Hydroxylamine (KAHA) Ligations with 5-Oxaproline (Angew. Chem. Int. Ed. 21/2012)
The chemical synthesis of proteins from unprotected peptide segments uses KAHA ligation with 5-oxaproline, which is incorporated readily into peptides by solid-phase peptide synthesis. Ligation of such protein segments in aqueous buffers with an α-ketoacid peptide gives an α-homoserine residue at th...
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| Published in: | Angewandte Chemie International Edition Vol. 51; no. 21; p. 5015 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Weinheim
Wiley Subscription Services, Inc
21-05-2012
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| Edition: | International ed. in English |
| Online Access: | Get full text |
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