P-429: Transforming growth factor [beta]1 and collagen type 1 and III in myocardial tissue in obese and lean Zucker rats

• Published in: American journal of hypertension Vol. 15; no. S3; p. 188A
• Main Authors: Toblli, Jorge E, Derosa, Graciela, Cao, Gabriel, Piorno, Pablo
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-04-2002
• ISSN: 0895-7061; 1941-7225
• DOI: 10.1016/S0895-7061(02)02780-2

High glucose concentration and insulin resistance states are both associated with a number of metabolic abnormalities in various tissues including myocardium. This study was to determine differences between obese (OZR) and lean (LZR) Zucker rats, which are a model of obesity and mild NIDDM, regarding morphological changes including immunostaining with TGFβ1 and two different types of collagen (Col I and Col III) in myocardium. 8-month-old male OZR (n= 8) G1 (fa/fa) and LZR (n= 8) G2 (Fa/fa) were used for this experiment. Hearts were processed for immunohistochemistry and LM.OZR presented a significant higher heart weight with lower myocyte and capillary density when compared with LZR. In addition, OZR showed an increase in either cardiac TGFβ 1 in interstitium as well as in vessel wall and both Col I and Col III, when compared with LZR. In conclusion, OZR present important morphological changes in myocardium, which could explain why congestive heart failure is highly prevalent in obesity and NIDDM. (See Table)