Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Inductions

Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Inductions

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Bibliographic Details
Published in:Drug metabolism and disposition Vol. 38; no. 1; pp. 16 - 24
Main Authors: KIM, Sean, DINCHUK, Joseph E, DULAC, Heidi A, PIZZANO, Jennifer, SINZ, Michael, ANTHONY, Monique N, ORCUTT, Tami, ZOECKLER, Mary E, SAUER, Mary B, MOSURE, Kathleen W, VUPPUGALLA, Ragini, GRACE, James E, SIMMERMACHER, Jean
Format: Journal Article
Language:English
Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 2010
Subjects:
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Human
Evaluation
Digestive system
Enzyme
Induction
Isozyme
Liver
Cytochrome P450
Pregnane X receptor
Prediction
Monkey
In vitro
In vivo
Vertebrata
Mammalia
Hepatocyte
Animal
Primary
Primates
Pharmacokinetics
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Description
ISSN:0090-9556
1521-009X