SARr and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 16; no. 5; pp. 1320 - 1323
Main Authors:	HERON, Nicola M, ANDERSON, Malcolm, MORTLOCK, Andrew A, PANNIFER, Andrew D, PAUPTIT, Richard A, PINK, Jennifer, ROBERTS, Nicola J, ROWSELL, Sian, BLOWERS, David P, BREED, Jason, EDEN, Jonathan M, GREEN, Stephen, HILL, George B, JOHNSON, Trevor, JUNG, Frederic H, MCMIKEN, Helen H. J
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 2006
Subjects:	Biological and medical sciences Medical sciences Miscellaneous Pharmacology. Drug treatments High throughput screening Nitrogen heterocycle Quinazoline derivatives Selectivity Morpholine derivatives Modeling Signal transduction Hydroxyether Structure activity relation Six membered ring Molecular model Piperidine derivatives Bicyclic compound Aromatic compound Aminoalcohol Enzyme Transferases Benzene derivatives Enzyme inhibitor Aminoether Inhibitor enzyme complex X ray diffraction In vitro Aurora kinases Kinase inhibitor: Anilino-quinazoline: Protein kinase inhibition Protein kinase Benzamide derivatives Pyrimidine derivatives Crystalline structure
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ISSN:	0960-894X 1464-3405