Neurotoxicity Induced by Cefepime in a Patient with Minimal Change Disease

• Published in: Kidney research and clinical practice pp. 796 - 801
• Main Authors: Seung Don Baek, Se Jeung Park, Chung Hee Baek, 구태연, 강중구, 김순배
• Format: Journal Article
• Language: English
• Published: 대한신장학회 01-11-2010
• Subjects: 내과학
• ISSN: 2211-9132; 2211-9140

A 71-year-old woman with minimal change disease visited our clinic complaining of pleuritic chest pain. Cefepime was given under the impression that she had pneumonia. Three days after cefepime administration, she became unconscious. A brain MRI scan was non-revealing and an EEG showed triphasic waves. As there was no evidence of septic, uremic or hepatic encephalopathy, we suspected cefepime-induced neurotoxicity. Cefepime was stopped and she underwent hemodialysis to decrease the blood levels of the drug. Following hemodialysis, she regained consciousness.
A 71-year-old woman with minimal change disease visited our clinic complaining of pleuritic chest pain. Cefepime was given under the impression that she had pneumonia. Three days after cefepime administration, she became unconscious. A brain MRI scan was non-revealing and an EEG showed triphasic waves. As there was no evidence of septic, uremic or hepatic encephalopathy, we suspected cefepime-induced neurotoxicity. Cefepime was stopped and she underwent hemodialysis to decrease the blood levels of the drug. Following hemodialysis, she regained consciousness. KCI Citation Count: 3