NF-κB Activation in T Helper 17 Cell Differentiation

NF-κB Activation in T Helper 17 Cell Differentiation

CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell diff...

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Bibliographic Details
Published in:Immune network pp. 14 - 20
Main Authors: 박상헌, 조가비, 박성규
Format: Journal Article
Language:English
Published: 대한면역학회 01-02-2014
Subjects:
면역학
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Summary:CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-κB activation pathway and its effect on Th17 cell differentiation. KCI Citation Count: 0
Bibliography:http://www.ncbi.nlm.nih.gov/pmc/journals/1113/
G704-001562.2014.14.1.007
ISSN:1598-2629
2092-6685
DOI:10.41110/in.2014.14.1.14