위암의 화학 예방 요법: 아스피린 포함 비스테로이드 소염제
Many reports have been published that provide epidemiological evidence supporting the efficacy of aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) in cancer prevention. The presumed mechanism of chemoprevention is inhibition of cyclooxygenase (COX)-2. Aspirin exhibits an anticancerous effe...
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| Published in: | The Korean journal of helicobacter and upper gastrointestinal research pp. 169 - 174 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | Korean |
| Published: |
대한상부위장관ㆍ헬리코박터학회
01-12-2017
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Many reports have been published that provide epidemiological evidence supporting the efficacy of aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) in cancer prevention. The presumed mechanism of chemoprevention is inhibition of cyclooxygenase (COX)-2. Aspirin exhibits an anticancerous effect through several inter-related mechanisms: prostaglandin synthesis and catabolism in epithelial cells, inhibition of Wnt-β‐catenin signaling, inactivation of platelets, and the host immune response. Several clinical studies have demonstrated that aspirin and NSAIDs exhibit chemopreventive effects in stomach cancer. However, well-designed clinical studies to answer critical clinical questions such as additional benefits of aspirin or NSAIDs after eradication of Helicobacter pylori, and the net benefit despite the adverse effects of long-term intake of aspirin or NSAIDs, are needed. (Korean J Helicobacter Up Gastrointest Res 2017;17:-174) KCI Citation Count: 0 |
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| Bibliography: | http://www.helicojournal.org/journal/view.html?uid=477&&vmd=Full |
| ISSN: | 1738-3331 2671-826X |
| DOI: | 10.7704/kjhugr.2017.17.4.169 |