간세포양 샘암종의 임상병리학적 특성

• Published in: The Korean journal of helicobacter and upper gastrointestinal research pp. 88 - 93
• Main Authors: 윤정빈, 김광하, 박도윤, 김영금, 편성익, 이봉은, 송근암
• Format: Journal Article
• Language: Korean
• Published: 대한상부위장관ㆍ헬리코박터학회 01-06-2017
• Subjects: 내과학
• ISSN: 1738-3331; 2671-826X
• DOI: 10.7704/kjhugr.2017.17.2.88

Background/Aims: Gastric hepatoid adenocarcinoma (GHA), a rare type of primary gastric cancer, is characterized by a histologyresembling hepatocellular carcinoma. Previous case studies reported that patients with GHA have a poor prognosis due to earlylymph node or liver metastasis, but information concerning GHA is still limited. Therefore, we aimed to evaluate the clinicopathologicalfeatures of GHA.
Materials and Methods: We reviewed the medical records of 9 patients who were diagnosed as having GHA between January 2011and December 2016. The clinicopathological characteristics of these patients were retrospectively analyzed.
Results: The median age of the patients at diagnosis was 68.9 years. Seven of the 9 patients were male. Serum AFP levels were elevatedin 3 of 4 patients. All the tumors were ＞4 cm (range, 4∼12 cm), and 7 tumors were located at the lower third of the stomach.
Five tumors were classified as Borrmann’s type 3, with a purple, berry-like surface. Of the 6 patients without distant metastasis, 5received curative-intent surgery and 3 received adjuvant chemotherapy. Three patients with distant metastasis received either palliativeoperation and/or chemotherapy. Their median survival time was 11.8 months (range, 1∼36 months). Two patients with elevatedserum CEA levels had poor outcomes.
Conclusions: GHA is a rare subtype of gastric cancer that is prone to liver metastasis. All GHAs are advanced gastric cancer witha purple, berry-like surface at diagnosis. Although the prognosis of advanced-stage GHA is poor, active multimodality treatmentmight provide some benefit. KCI Citation Count: 0