Quercetin-3-O-b-D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells

• Published in: Archives of pharmacal research pp. 1219 - 1233
• Main Authors: Hyo Hyun Yang, 황보경, Ming Shan ZHENG, 조정희, 손종근, 김화영, 백석환, 최형철, 박소영, 김재룡
• Format: Journal Article
• Language: English
• Published: 대한약학회 01-09-2014
• Subjects: 약학
• ISSN: 0253-6269; 1976-3786

Cellular senescence is known to contribute totissue aging, a variety of age-related diseases, tissue regeneration,and cancer. Therefore, aging intervention might beuseful for prevention of aging as well as age-related disease.
In this study, we investigated compounds from Polygonumaviculare to determine if they inhibited cellular senescencein human primary cells, human dermal fibroblasts (HDFs)and human umbilical vein endothelial cells (HUVECs). Tencompounds from P. aviculare were purified and theirinhibitory effects on adriamycin-induced cellular senescencewere measured by observing senescence-associated bgalactosidase(SA-b-gal) activity and reactive oxygen species.
Among them, compound 9 (quercetin-3-O-b-D-glucuronide)showed inhibitory effects against cellular senescencein HDFs and HUVECs treated with adriamycin. Additionally,compound 9 rescued replicative senescence in HDFs and HUVECs. These data imply that compound 9 repressescellular senescence in human primary cells and might beuseful for the development of dietary supplements or cosmeticsthat ameliorate tissue aging or aging-associated diseases. KCI Citation Count: 17