Human LZIP induces monocyte CC chemokine receptor 2expression leading to enhancement of monocytechemoattractant protein 1/CCL2-induced cell migration

• Published in: Experimental & molecular medicine pp. 332 - 338
• Main Authors: 성호중, 김윤석, 강혜린, 고제상
• Format: Journal Article
• Language: English
• Published: 생화학분자생물학회 01-06-2008
• Subjects: 생화학
• ISSN: 1226-3613; 2092-6413

Chemokines and chemokine receptors play a role in inflamation. Human LZIP is an uncharacterized tran-scription factor and is known to participate in leuko-tactin (Lkn)-1/CCL15-induced cell migration. We in-vestigated the role of human LZIP in expression of C chemokine receptors (CCRs) and its involvement in monocyte migration. RNase protection analysis showed that LZIP increased mRNA expression of CCR2 and CCR1 in THP-1 cells. Surface expressions of both CCR2 and CCR1 were also increased by LZIP. oretic mobility shift assay showed that LZIP binds to the C/EBP element in the CCR2 promoter. LZIP also enhanced the chemotactic activities of monocyte chemoatractant protein-1/CCL2 and Lkn-1. These results suggest that LZIP regulates expression of chemokine receptors that are involved in monocyte migration. KCI Citation Count: 11