Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo

Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo

Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low...

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Bibliographic Details
Published in:Korean journal of parasitology Vol. 59; no. 3; pp. 297 - 301
Main Authors: Zhang, Run-Hui, Jin, Runhao, Deng, Hao, Shen, Qing-Kun, Quan, Zhe-Shan, Jin, Chun-Mei
Format: Journal Article
Language:Korean
Published: 2021
Subjects:
Toxoplasma gondii
hederagenin
in vitro
inhibition
in vivo
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Summary:Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.
Bibliography:KISTI1.1003/JNL.JAKO202119062034704
ISSN:0023-4001
1738-0006