Distribution and Features of the Six Classes of Peroxiredoxins

• Published in: Molecules and cells Vol. 39; no. 1; pp. 53 - 59
• Main Authors: Poole, Leslie B, Nelson, Kimberly J
• Format: Journal Article
• Language: Korean
• Published: 2016
• Subjects: disulfide reductase; peroxide reductase; thiol peroxidase; active site profiling; bioinformatics
• ISSN: 1016-8478; 0219-1032

Peroxiredoxins are cysteine-dependent peroxide reductases that group into 6 different, structurally discernable classes. In 2011, our research team reported the application of a bioinformatic approach called active site profiling to extract active site-proximal sequence segments from the 29 distinct, structurally-characterized peroxiredoxins available at the time. These extracted sequences were then used to create unique profiles for the six groups which were subsequently used to search GenBank(nr), allowing identification of ~3500 peroxiredoxin sequences and their respective subgroups. Summarized in this minireview are the features and phylogenetic distributions of each of these peroxiredoxin subgroups; an example is also provided illustrating the use of the web accessible, searchable database known as PREX to identify subfamily-specific peroxiredoxin sequences for the organism Vitis vinifera (grape).