Utility of Serum and Urine uPAR Levels for Diagnosis of Breast Cancer

Utility of Serum and Urine uPAR Levels for Diagnosis of Breast Cancer

Malignant tumors have a capacity to degrade the extracellular matrix by controlled proteolysis. One system involved in these processes is the urokinase-type plasminogen activator (uPA) system. uPAR levels are elevated in tumors from several types of cancer. Our study was planned to investigate serum...

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Bibliographic Details
Published in:Asian Pacific journal of cancer prevention : APJCP Vol. 13; no. 6; pp. 2887 - 2889
Main Authors: Soydinc, Hilal Oguz, Duranyildiz, Derya, Guney, Nese, Derin, Duygu, Yasasever, Vildan
Format: Journal Article
Language:Korean
Published: 2012
Subjects:
invasion & metastasis
Tumor markers
breast cancer
uPAR
biochemical markers
cancer biomarkers
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Summary:Malignant tumors have a capacity to degrade the extracellular matrix by controlled proteolysis. One system involved in these processes is the urokinase-type plasminogen activator (uPA) system. uPAR levels are elevated in tumors from several types of cancer. Our study was planned to investigate serum and urine levels of uPAR in breast cancer patients (n=180) and healthy controls (n=60) by ELISA. Serum (p<0.001) and urine (p<0.001) uPAR values in the patients were both significantly elevated. High serum and urine levels of uPAR can be used as diagnostic tools in lymph node positive patients.
Bibliography:KISTI1.1003/JNL.JAKO201227935975868
ISSN:1513-7368
2476-762X