A New Cytotoxic Prenylated Dihydrobenzofuran Derivative and Other Chemical Constituents from the Rhizomes of Atractylodes lancea DC

A New Cytotoxic Prenylated Dihydrobenzofuran Derivative and Other Chemical Constituents from the Rhizomes of Atractylodes lancea DC

A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraceae), along with ten known compounds, including atractylenolide II (2), $\varphi$-taraxasteryl acetate (3), taraxerol acetate (4), $\beta$-sitosterol (5), stigmasterol (6), $\beta$-eud...

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Bibliographic Details
Published in:Archives of pharmacal research Vol. 31; no. 8; pp. 965 - 969
Main Authors: Duan, Jin-Ao, Wang, Liuying, Qian, Shihui, Su, Shulan, Tang, Yuping
Format: Journal Article
Language:Korean
Published: 2008
Subjects:
Atractylodes lancea
Asteraceae
Atractylenolide
Dihydrobenzofuran
Cytotoxicity
Constituent
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Summary:A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraceae), along with ten known compounds, including atractylenolide II (2), $\varphi$-taraxasteryl acetate (3), taraxerol acetate (4), $\beta$-sitosterol (5), stigmasterol (6), $\beta$-eudesmol (7), atractylenolide III (8), atractylenolide IV (9), daucosterol (10), and stigmasterol 3-O-$\beta$-D-glucopyranoside (11). The structure of the new compound (1) was elucidated as trans-2-hydroxyisoxypropyl-3-hydroxy-7-isopentene-2,3-dihydrobenzofuran-5-carboxylic acid by the combination of 1D, 2D NMR analysis and mass spectrometry, and it was the first reported 2,3-dihydrobenzofuran derivative having a carboxyl residue at C-5 and an isopentene moiety at C-7 contemporaneously. In addition, compound 1 exhibited significant cytotoxicity against cancer cell lines HCT-116 and MKN-45.
Bibliography:KISTI1.1003/JNL.JAKO200827364487231
ISSN:0253-6269
1976-3786