국소 진행성 식도 편평상피세포암 환자에서 식도 절제술과 동시 화학 방사선 치료의 임상적 결과 비교

• Published in: The Korean journal of gastroenterology Vol. 83; no. 3; pp. 102 - 110
• Main Authors: 이명훈, Myung Hun Lee, 박무인, Moo In Park, 이주원, Ju Won Lee, 정경원, Kyoungwon Jung, 김재현, Jae Hyun Kim, 김성은, Sung Eun Kim, 문원, Won Moon, 박선자, Seun Ja Park
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 31-03-2024
• Subjects: Chemoradiotherapy; Esophageal squamous cell carcinoma; Esophagectomy
• ISSN: 1598-9992

Background/Aims: The efficacy of concurrent chemoradiotherapy (CCRT) or esophagectomy for locally advanced esophageal squamous cell carcinoma (ESCC) is unclear. This study compared the survival and recurrence of patients with locally advanced ESCC after definitive CCRT and surgery.
Methods: A retrospective study was conducted on patients with locally advanced ESCC who underwent CCRT or esophagectomy at Kosin University Gospel Hospital from January 2010 to December 2016. The patients’ baseline characteristics, pathology, recurrence rate, and three-year/five-year overall survival were obtained
Results: This study evaluated ESCC patients with cT1-T2, N+ or cT3-T4, or N, who were treated by definitive CCRT (n=14) or esophagectomy (n=32). No significant difference was noted between the two groups, except for the location of the cancer and performance state. The respective three- and five-year overall survival rates were 30.8% and 23.1% in the CCRT group and 40.2% and 22.5% in the esophagectomy group (p=0.685). In the CCRT group, three patients (21.4%) had a complete response, and two (66.7%) had a recurrence. In the esophagectomy group, an R0 resection was achieved in 28 (87.5%) patients, and a recurrence occurred in 18 (64.3%). The median disease-free survival in the CCRT and esophagectomy groups was 14 and 17 months, respectively (p=0.882).
Conclusions: These results showed no significant difference in survival between the definitive CCRT and surgery as the initial treatment. Nevertheless, larger prospective studies will be needed because of the retrospective nature and small number of patients in this study. (Korean J Gastroenterol 2024;83:102-110)