위의 CD56 음성 자연살해 T세포 림프종 1예

• Published in: The Korean journal of gastroenterology Vol. 80; no. 4; pp. 190 - 194
• Main Authors: 정주홍, Joohong Chung, 지삼룡, Sam Ryong Jee, 최은정, Eunjeong Choi, 유승정, Seung Jung Yu, 윤준식, Jun Sik Yoon, 이홍섭, Hong Sub Lee, 이상헌, Sang Heon Lee, 박성재, Sung Jae Park, 박하영, Ha Young Park
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 31-10-2022
• Subjects: CD56 antigen; extranodal NK-T-cell; Lymphoma; Stomach ulcer; T-lymphocytes
• ISSN: 1598-9992

Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL-NT) is the most common subtype of Epstein-Barr virus-associated NK/T-cell lymphomas. ENKTCL-NT occurs infrequently in the gastrointestinal tract. In particular, reports of ENKTCL-on NT arising from the stomach are extremely rare. Several clusters of differentiation (CDs) have been useful in recognizing NK-cells, T-cells, and tumor cells of NK/T-cell lymphomas. Among them, the CD56 antigen is considered the most sensitive marker for ENKTCL-NT and is expressed in almost all cases of ENKTCL-NT. Thus, the development of CD56-negative ENKTCL-NT is highly atypical. This paper reports a case of a young Asian female who presented with gastric ulcer bleeding. The patient was histologically diagnosed with ENKTCL-NT. No tumor cells for CD56 were observed, whereas no monoclonality of the T-cell receptor gamma gene rearrangement was detected in the tumor cells. The patient was scheduled for systemic chemotherapy six times and achieved complete remission. Peripheral blood-hematopoietic stem cell transplantation was performed later. (Korean J Gastroenterol 2022;80: 190-194)