단보 : α-Glucosidase 저해물질을 함유한 노랑느타리버섯(Pleurotus cornucopiae) 물추출물의 혈당상승 억제 효과

• Published in: Hangug gynnhaghoi ji Vol. 44; no. 1; pp. 57 - 60
• Main Authors: 신자원, Ja Won Shin, 배상민, Sang Min Bae, 한상민, Sang Min Han, 이윤혜, Yun Hae Lee, 정윤경, Youn Kyung Jeong, 지정현, Jeong Hyun Ji, 이종수, Jong Soo Lee
• Format: Journal Article
• Language: Korean
• Published: 한국균학회 31-03-2016
• Subjects: Antihyperglycemic effects; Pleurotus cornucopiae; Water extracts; α-Glucosidase inhibitor
• ISSN: 0253-651X; 2383-5249

식용버섯 자실체를 이용하여 새로운 식후 혈당상승억제 물질을 개발하기 위하여 노랑느타리버섯 자실체에 함유되어있는 α-glucosidase 저해물질을 증류수로 추출하여 식후 혈당 상승억제효과를 조사하였다. α-Glucosidase 저해물질을 함유한 노랑느타리버섯 물추출물은 streptozotocin으로 당뇨를 유발시킨 당뇨 쥐에서 장기 30 mg/kg, 150 mg/kg 경구투여(2일)와 단기 500 mg/kg, 1,000 mg/kg 경구투여(120분)시 모두, 농도 의존적으로 식후 혈당상승억제 효과를 보였다.
Following preparation of water extracts of Pleurotus cornucopiae fruiting body-containing α-glucosidase inhibitor, their antihyperglycemic effects were examined using streptozotocin-induced diabetic Sprague-Dawley (SD)-rats. The water extracts from Pleurotus cornucopiae showed dosage-dependant antihyperglycemic effects on the streptozotocin-induced diabetic SD-rats after oral administration to 120 min on the short time test and 4 days on the long time test, respectively. The water extracts from Pleurotus cornucopiae fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min and 4 days in the SD-rat and streptozotocin-induced diabetic SD-rat.