Recent Chemotherapy Reduces the Maximum-Standardized Uptake Value of 18F-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer

• Published in: Gut and liver Vol. 8; no. 3; pp. 254 - 264
• Main Authors: Ji Won Kim, Young Hoon Choi, Ji Min Choi, Shin Ae Lee, Minjong Lee, Yoo Min Han, Tae Sung Yeum, Hong Ran Moon, Dong Kee Jang, So Hee Oh
• Format: Journal Article
• Language: Korean
• Published: 대한소화기내시경학회 30-05-2014
• Subjects: Colorectal neoplasms; Drug therapy; FDG-PET/CT
• ISSN: 1976-2283

Background/Aims: The aim of this study was to evaluate the influence of recent chemotherapy on the patterns of the maximum-standardized uptake value (M-SUV) and sensitivity of 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in colorectal cancer. Methods: We retrospectively analyzed the FDG-PET/CT of 509 patients who underwent surgery for colorectal cancer. Subgroup analysis was performed according to chemo­therapy status; 401 patients were not treated with chemo­therapy and 108 patients were treated with chemotherapy within 6 months prior to surgery. Pathologic analysis of the surgical specimen was used as the gold standard. Results: The M-SUV was significantly lower in patients treated with chemotherapy than in those not treated with chemotherapy in pathologically confirmed same stages of disease. The difference in the sensitivity of the M-SUV according to che­motherapy status was greatest using a cutoff M-SUV value of 6.4 (p<0.001). The longest diameter of the primary tumor was the most important factor that correlated with M-SUV of the primary tumor irrespective of the chemotherapy effect (p<0.001). The M-SUV of the primary tumor was not an in­dependent predictor of lymph node metastasis in colorectal cancer. Conclusions: The results indicate that the M-SUV of FDG-PET/CT should be interpreted in the context of concur­rent chemotherapy.(Gut Liver 2014;8:254-264)